A Clinical Study on the Effect of Anti_Hyperosteogeny Analgesic Plaster on Osteoarthritis

YANG Ye_qing

(The Affiliated Hospital of Guangdong Medical College,Guangdong Zhanj iang 524001)

abstract:Seventy_five cases of osteoarthritis were allocat ed to two groups:Group Ⅰ(50，treated with anti_hyperosteogeny analgesic plaster) and Group Ⅱ(25，tre a ted with Guyouling lotion).The results showed that the markedly effective rate w as 18%,the effective rate was 66% and the total effective rate was 84%.In Group Ⅰ，the differences being not significant as compared with Group Ⅱ.This indicat es the effect of anti_hyperosteogeny analgesic plaster on osteoarthritis is simi lar to Guyouling lotion and no obvious toxic and side effects w as exerted.

Key words:@ Anti_hyperosteogeny Analgesic pla ster/therapeutic use;Osteoarthritis/TCM therapy

(original article on page 138)

A Clinical Observation of Yufeng Ningxin Granul e for Angina Pectoris

WANG Cui_ping,GUO Wei_xing,SU Wen_ge,et al.

(The Affiliated Hospital of Shandong University of TCM,Shandong Jinan 250011)

abstract:The effects of Yufeng Ningxin Granule(YNG)in treating 105 cases of angina pectoris(AP)were reported.Another group of 1 05 patients treated with Yufeng Ningxin tablet(YNT)served as control.The results showed that the total effective rate in the YNG group(89.5%)was higher than that in the contro l g roup(79.0%),the difference being significant(P＜0.05).The effective rates on ECG in the two groups were 57.9% and 46.3% r espectively(P＞0.05).The symptoms of chest d istress,c hest pain,palpitation and dizziness caused by AP in the YNG gro up were markedly improved as compared with those in the YNT group(P＜0.05～0. 01).It is revealed that YNG can decrease blood pressure, regulate blood_lipid metabolism and improve blood viscosity.

Key words:@ Yufeng Ningxin Granule/therapeuti c use;Corona ry disease/TCM therapy;Angina pectoris/TCM therapy;Hypertension/TCM therapy

(original article on page141)

Effects of Huoxin Wan on Isolated Myocardium of Guinea Pig

and Hemodynamics of Anesthetized Dog in Vivo

LI Zhong_si¹，ZHANG Xiao_na¹,WAN Jin_qun²,et al.

(1.Pharmaceutical Research Centre,Guangzhou Baiyunshan Pharmaceutical Co.,Ltd,Guangdong Guangzhou 511051;

2.Department of Pharmacology,SUN Yat_sen University of Medical Science,Guangdon g Guangzhou 510089)

abstract:The effects of Chinese patent medicine,Huox in Wan,on isolated myocardiu m of guinea pig and hemodynamics of anesthetized dog in vivo were studied.It was shown that Huoxin Wan imprved both systolic and diastolic func tion of isolated papilary muscle(T_max,+dp/dt_max,-dp/dt_max)were enhanced,the contractility of the isolated right atrium was increased but spontaneous rhythm unaffected,and the excitability threshold of the isolated left ventricle was dec reased. It was also shown that Huoxin Wan can increase the myoc ardial contractility and excitability directly.As to the hemodynamics,LVP_max was increas ed,+dp/dt_max accelerated,CO increased and LVEDP decreased,indicating that Huoxin Wan can enhance the pump function of the heart,decreased heart rate and myocardial oxygen consumption,and enhance the diastolic function.

Key words:@ Huoxin Wan/pharmacology;Myo card ial Contraction/drug effect;Hemodynamics/drug effect;Myocardial Ischemia/prevent ion & control;In Vitro

(original article on page 149)

Effect of Nao Yi Qing Capsule on Memory i n Aged Mice and Dementia Mimetic Rats

HUANG Shi_fu,LIANG Qi_yong,CHEN Qin,et al.

(Anhui Institute of Pharmacy,Anhui Hefei,230022)

abstract:The effect and mechanism of Nao Yi Qing Capsule(NYQ)on memory in aged mouse and dementia mimetic ra t model which was set up with aluminum chloride solution were studied.The result s showed that the M_cholinergic receptor was lowerd in the aged mice(P[ WT5BZ〗＜0.01)and the activity of acetylcholinesterase(AchE)was inc reas ed in the cerebral cortex of dementia mimetic rats(P＜0.0 1)as compared with the healthy young animals.NYQ could m arkedly reduce the AchE activity and elevate the M_cholinergic receptor( P＜0.05～0.01)in the cerebral cortex,and improve their mem ory.These results suggest that NYQ is effective in preventing t he retrogression of cerebral function and beneficial for the treatment of senile dementia.

Key words:@ Nao Yi Qing Capsule/pharmacology; Memory/drug effect;Cholin esterases/analysis;Receptors,Cholinergic/analysis;Dementia,Senile/TCM therapy

(original article on page 153)

An Experimental Study on Short_term Nephrotoxicity of Da nggui Sini Decoction

Added with Wuzhuyu and Shengjiang,and Caulis Aristolochiae Manshuriensis in Mice

MA Hong_mei,ZHANG Bo_li,FAN Ying_chang,et al.

(Tianjin College of TCM,Tianjin 300193)

abstract:The short_term nephrotoxicity of Danggui Sini [ WT5BZ〗Decoction added with Wuzhuyu shengjiang(DSDWS)and Cau lis Aristolochiae Manshuriensis(CAM)in mice was investigated.Dosages of 30 g/kg and 9g/kg were fed by gastric tube daily for 7 days.Body weight,hemoglo bin,renal functions and histomorphology of mice were observed.After 7 days,body weight,proteinuria and renal histomorphology were abnormal in both DSDWS and CAM groups,and the differeneces were significant as compared with control group(P＜0.05).The above results indicate that the nephrotoxicity of DSDWS and CAM is similar.

Key words:@ Danggui sini decoction Added with Wuzhuyu and Shengjiang/toxicity;Cauli s Aristolochiae Man shuriensis/toxicity;Kidney/drug effect;Mice

(original article on page 156)

Effects of Qiongyu Gao on Nervous System of Agi ng Mice

XUE Yu_fang¹，LI Zhen_bo²

(The First Affiliated Hospital，Guangzhou University of TCM,Guangdong Guangzhou 510405)

abstract:Effects of Qiongyu Gao(QG)on nervous system of aging mice were observed at cellular and molecular levels.The results showed that QG had a good regulatory effect on the learning an d memory ability of the aging mice,increased the antioxidation of hypothalamus,r educed the pathologic damages induced by peroxidation,lessened the decrease of m onoamine neural transmitter in the brain and relieved the disturbance of neural transmitter metabolism.It is indicated that QG acts on the nerv ous system at various levels and can delay the aging process and relieve the agi ng symptoms.

Key words:@ Qiongyu Gao/pharmacology;Aging/drug effect;Hypo thalamus/chemistry;Cerebral Cortex/chemistry;Neurotransmitters/chemistry;Mice

(original article on page 159)

Pharmacokinetics of Fructus Psoraleae in Bile E limination

YE Shao_mei,