关键词： 肿瘤坏死因子，抗癌作用，联合用药，化学修饰，定位基因突变，现状

摘要：综述了近年来有关肿瘤坏死因子(TNF)的抗癌机制，单独、联合用药和基因疗法的初步效果，以及化学修饰和基因定位突变对TNF的增效减毒作用。强调应特别重视TNF可能产生的负面效应。

分类号：R979.1

Research Status Of Aticancer Effect of Tumor Necrosis Factor

xiong Shaoyin,Jin Yali,Liu Suqing,Zhang Qiuhong(Department of Pharmacy, General Hospital of Nanjing Command PLA Najing 210002)

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收稿日期：1999-03-11

修稿日期：1999-12-03