关键词： 低分子量肝素钠，法安明，不稳定性心绞痛

摘要：目的：比较国产与进口低分子量肝素钠注射液(LMWH)在治疗不稳定性心绞痛方面的临床疗效。方法：治疗组与对照组各30例，腹壁皮下脂肪内注射，剂量为100抗XaIU／(kg·12h)，连续7d。结果：国产LMWH治疗不稳定性心绞痛显效率及有效率分别为33.3％和83.3％，与进口低分子量肝素钠注射液(法安明)的30.0％和80.0％无显著差异。结论：国产LMWH对不稳定性心绞痛的治疗安全有效，且与进口同类产品相一致。

分类号：R972.3

Comparison between China-made and Exported Low Molecular Weight Heparin Sodium in Treating Unstable Angina Pectories

he Shuying,Wu Huirong,Zhang Wanwen,Zhang Hui,Lu Fengxiang,Huang Yuanzhu(Nangjing University Pharmaceutical Factory Nanjing 210093)

Abstract：Purpose: To compare the therapeutic effects of China-made LMWH and exported LMWH(Fragmin). Methods:Treatment group and control group both have 30 patients and two subcutaneous injection daily for 7 days (100 antiXaIU/(kg·12h). Results: The remarkable improving rate and improving rate of China-made LMWH are 33.3％ and 83.3％ respectively and there is no notable difference with exported Fragmin (30.0％ and 80.0％). Conclusion: It is proved that China-made LMWH in tratment of unstable angina pectories is both effective and safe.

Keywords：Low molecular weight heparin, Fragmin, Unstable angina pectories

参考文献：

［1］Fareed J，Jeske W，Eschenfelder V，et al. Preclinical studies on low molecular weight heparin．Thrombosis Reseach，1996，81(2)：1～27

［2］房溶娟，裘宇芳，朱敏，等．肝素与低分子肝素治疗不稳定心绞痛的比较．中国新药与临床杂志，1998，17(4)：197～199

［3］尤蓓．低分子量肝素与心血管疾病．国外医学——心血管疾病分册，1997，24(5)：19～22

收稿日期：1999-03-15

修稿日期：1999-10-10