关键词： 蜂胶提取物，肿瘤，化疗药物

摘要：目的：探讨蜂胶提取物抗肿瘤及减轻化疗药物毒性的作用。方法：通过整体动物实验，将昆明小鼠移植S180肉瘤，观察蜂胶提取物抑制肿瘤作用及与化疗药物合用时的协同及减毒作用。结果：蜂胶提取物的抑瘤率为27.74％，与环磷酰胺合用的抑瘤率为50.32％，比单用蜂胶提取物及环磷酰胺分别提高22.58％和9.03％(P＜0.05)，并能减轻环磷酰胺所致的骨髓造血功能抑制，使血液白细胞维持在正常水平(P＜0.01)。结论：蜂胶提取物与环磷酰胺合用有协同抗肿瘤作用，并能减轻肿瘤化疗药物的毒副作用。

分类号：R979.1

Experimental and Clinical Studies on the Effect of Extract of Propolis on Decreasing the Toxicity of Chemotherapeutant

gao Chunyi,Zhang Jian,Zhao Yueran,You Li,Feng Jinbo,Tian Zhigang(Institute of Basic Medicine of Shandong Academy of Medical Science Jinan 250062)

Abstract：Purpose: To study propolis extract antitumor effect and its lowering of the toxicity caused by chemotherapeutant. Methods: Kunming mice transplanted with S180 sarcoma were used to study the inhibition effect of propolis extract on tumor, and its lowering of toxicity caused by synergy with chemotherapeutant. Results: The extract of propolis had certain antineoplasm effect and the inhibition rate of propolis extract on tumor is 27.74％ and when combined with cyclophosphamide, the inhibition rate reached to 50.32％, even antagonized leucocytopenia caused by cyclophosphamide. Conclusion: The extract of propolis could relieve leucocytopenia and thrombocytopenia caused by chemotherapeuant clearly.

Keywords：Extract of propolis, Tumor, Chemotherapeutant参考文献：

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收稿日期：1999-06-11

修稿日期：2000-02-15