关键词： DAN拓扑异构酶，拓扑异构酶抑制剂，抗肿瘤

摘要：拓扑异构酶控制、维持和修饰DNA拓扑结构。拓扑异构酶抑制剂通过作用于拓扑异构酶，对很多肿瘤发挥抑制活性。论述了拓扑异构酶抑制剂的作用机理、杀伤肿瘤细胞的机制及耐药性问题。

Topoisomerase Inhibitors——A New Type of Anti-tumor Drug

mao Xiaoqing,Chen Junhui(Pharmaceutical Biotechnology Key Laboratory,Department of Biochemistry,Nanjing University(Nanjing21OO93)

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收稿日期：1999-01-18