目的：本研究通过观察经皮冠状动脉腔内成形术(PTCA)后血浆内皮素(ET)及前列环素(PGI₂)的代谢产物6-酮-前列腺素F_1α(6-酮-F_1α)水平的改变，探讨其在PTCA后冠状动脉收缩中的可能作用。

方法：对21例冠状动脉造影及19例PTCA患者检测血浆ET和PGI₂的代谢产物6-酮-F_1α的变化。

结果：单纯冠状动脉造影的患者血浆ET及6-酮-F_1α在手术前后无明显的变化(P＞0.05),而PTCA后24小时血浆ET和6-酮-F_1α较术前明显升高(P＜0.05),术后1周又复降至接近术前水平(P＞0.05)。单支血管和多支血管的PTCA，血浆ET和6-酮-F_1α浓度变化比较均无统计学差异(P＞0.05)。

结论：在PTCA 24小时后应注意防止血小板聚集和血栓形成，术后1周内最好服用预防冠状动脉痉挛药物。

Changes and Significance of Plasma Endothelin and Prostacyclin Level after Percutaneous Transluminal Coronary Angioplasty in Patients with Coronary Heart Disease (Abstract)

Department of Cardiology, Tianjin Chest Hospital, Tianjin (300051)

Qin Qin, Zhao Bingrang.

Objective: To investigate the action of endothelin (ET) and a metabolite of prostacyclin, 6-keto-F_1α after percutaneous transluminal coronary angioplasty in coronary constriction.

Methods: Plasma ET and a metabolite of prostacyclin 6-keto-F_1α, levels were tested in 21 cases undergoing coronary angiography and 19 patients undergoing percutaneous transluminal coronary angioplasty.

Results: Plasma ET and 6-keto-F_1α levels did not change significantly before and after coronary angiography (p＞0.05), however they were significantly increased 24 hours after percutaneous transluminal coronary angioplasty (PTCA) (p＜0.05). The levels decreased close to baseline within a week after PTCA (p＞0.05). No significant differences in plasma ET and 6-keto-F_1α levels between single and multivessel PTCA were observed after the procedure (p＞0.05).

Conclusion: It was essential to protect from platelet aggregation and thrombosis from 24 hours after PTCA and to take prophylactic drugs to avoid coronary spasm in the first week after PTCA.