摘要：目的验证新的测定肾小球滤过率(GFR)的方法——碘海醇清除率作为判断GFR的临床意义。方法对19例不同肾功能的患者同时进行99mTc-DTPA清除率及碘海醇清除率的测定，以99mTc-DTPA清除率为标准方法，对两组结果进行相关分析。血、尿标本中碘海醇的测定采用X-射线荧光分析法。结果碘海醇清除率与99mTc-DTPA清除率有高度相关性(r=0．98)。结论碘海醇清除率是一种较安全、可靠、无放射性的测定GFR的方法。

Clearance of iohexol——a new method to determine GFR

XIN Gang ,QI Huimin ,LI Jingzi,et al.

(Department of Nepbrology,the First Hospital,Beijing Medical University,Beijing 100034,China)

Abstract：Objective To investigate the feasibility whether clearance of iohexol can be a reliable,sensitive and safe method for the determination of GFR.Methods The GFR of 19 patients with different renal functions were examined using clearance of 99m Tc-DTPA and clearance of iohexol.Then the correlation of them was analyzed.Serum and urinary iohexol was determined by X-ray fluorescence analysis.Results These two methods were significantly correlated (r= 0.98 ).Conclusion Clearance of iohexol is a safe,confident,no-radioactivity method for the clinical practice of GFR determination.

Keywords：Glomerular filtration rate;Iohexol;Clearance;X-ray fluorescence spectrometry

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收稿日期：2000-02-19