摘要：对视黄醇结合蛋白(RBP)的临床应用进行了综述。RBP为血液中转运视黄醇的蛋白，半衰期短，体内含量较少，能较为灵敏地反映机体营养状况。RBP含量改变也能早期反映各种肾脏疾患及肝功能损害程度。参考文献：

［1］Torres Y, Torres N. Advances in vitamin A and retinaid-binding proreins. Rev Invest clin, 1995, 47: 149.

［2］Lindblad BS, Patel M, Hamadeh M, et al. Age and sex ere important factors in determing normal retinal levels. J Trop pediatr, 1998, 44: 96.

［3］Sundaram M, Sivaprasadarao A, Desousa M, et al. The transfer of retinol from serum retinal hinding protein to cellular retinol binding protein is mediated by a membrane receptor. J Biol chem, 1998, 273 :3336.

［4］Hodam J, Cree K. Comparison of the metabolism of retinol delibered to human keratinocytes either bound to serum retinol-binding protein or added directly to the culture medium. Exp Cell Res, 1998, 238: 257.

［5］Benabdeslam H, Garcia I, Brllon G, et al. Biochemical assessmant of the nutritional status of cystic fibrosis patients treated with pancreatic enzyme extracts. Am J Clin nutr, 1998, 67: 912.

［6］Ihera H, Shino Y, Hashizume N, et al. Decline in plasma retinol in unconjugated hyperbilirubinemia treated with bilirubin adsorption usng an anion exchange resin. J Nutr Sci vit, 1998, 44: 329.

［7］Lespine A, Periquet B, Jaconi S, et al. Decreases in retinal and retinal-binding protein during total perentersl nutrition in rats are not due to a vitamin A deficiency. J Lipid res, 1996, 37: 2492.

［8］Ellis D, Forrest KY, Erbey F, et al. Urinary measurement of transforming growth factor-beta and type Ⅳ collagen es new markers of renal injury: application in diabetic nephropathy. Clin chem, 1998, 44: 950.

［9］Stefano J, Keith G, Graham J, et al. Cheraterization of two post translationslly processed forms of human serum retinal binding protein: altered ratios in chronic rend failure. J Lipid res, 1995, 36: 1247.

［10］Aguiera A, Codoceo R, Selgas R, et al. Anorexigen (TNF-alpha, cholecystokinin) and orexigen (neuropeptide Y) plasma levels in peritoneal dialysis (PD) patients: their relationship with nutritional parameters. Nephrol Dial Transplant, 1998, 13: 1476.

［11］Pai P, Stevenson A, Mason H, et al. Occupational hydrocarbon exposure and nephrotoxicity: cohort study and literature review. Postgrad Med J, 1998, 74: 225.

［12］Mestroianni A, Regalia E, Fswhrtti G, et al. Increased retinol binding protein in the of patients with severe isehemic damage of the liver after transplantation. Clin biochem, 1998, 31: 113.

［13］Barga M, Vignali A, Gianotti A, et al. Immune and nutritional effects of early enteral nutrition after major abdominal operations. Eur J surg, 1996, 162: 105.

［14］Valasques G, Roncada MJ, Topovski J, et al. Relationship between acute diarrhoea and low plasma levels of vitamin A and relation binding protein. Rev Inst Med Trop Sao panlo, 1996, 38: 365.

［15］Git CI, Gimemo UC, Cos Al, et al. The nutritional status and respiratory function of patients diagnosed with cOPD. Nutr Husp, 1995, 10: 87.

［16］Casari A, Muttini S, Leggieri C, et al. Rapid turnover proteins in critically ill ICU patients. Minerva anestesiol, 1998, 64: 345.

收稿日期：1999-09-21

修稿日期：1999-10-26