摘要哺乳动物体内不同部位内皮细胞的生物活性状态，与其局部的血流剪切密切相关。通过建立动脉血流改变的动物模型检测发现，内皮细胞的形态、骨架结构、细胞间连接及增殖和调亡状态，会随之发生改变，这种变化依赖于壁剪应力的大小与作用时间。提示内皮细胞不仅具有选择性通透屏障的作用和合成分泌功能，而且还可感受机械应力的改变，并随之作出适应性改建。

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