摘要本文综述了关于NO和CO作为重要神经递质和神经内分泌轴的生物递质的相关文献。表明NO通过控制下丘脑分泌促性腺激素释放激素(GnRH)在生殖调控中起重要作用。NO有效地刺激GnRH分泌并调控GnRH分泌的主要递质谷氨酸的活动。资料显示NO刺激GnRH释放是由于其具有调节血红素酶系和产生第二信使分子cGMP的鸟甘酸环化酶的能力。NO合酶(NOS)的抑制剂和反义寡核甘酸减少类固醇诱导和卵前黄体生成素(LH)分泌。在体外，血红素分子刺激GnRH释放需要血红素加氧化酶的参与可被气体清洁分子血红蛋白阻断，说明CO刺激GnRH分泌。同时本文综述了NO抑制各种因素如白介素-1β，血管加压素和炎症对下丘脑-垂体-肾上腺轴(HAP)的作用。

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