摘要胶原酶是一种基质金属蛋白酶，参与体内胶原的分解代谢。其活性在酶基因表达、酶的活化和失活几个方面受到多种因素调控，基质金属蛋白酶抑制因子是胶原酶活性最重要的抑制因子。在皮肤的伤口愈合过程中，胶原酶及其组织抑制物相互作用，分解胶原，加速伤口愈合。

国家自然科学基金重点资助项目No.39830390

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