摘要：上橄榄核簇(SOC)是与听信号传导有关的脑干听觉初级中枢，并参与双耳间声信号的加工和声音的空间定位，在听觉形成中起重要作用。SOC可分为内侧上橄榄核(MSO)、外侧上橄榄核(LSO)、斜方体核(NTB)和橄榄周核(PON)，各个亚核在细胞构筑、纤维联系、神经信息物质及在听觉中的作用等方面是不同的。SOC内神经信息物质包括乙酰胆碱及氨基酸类、神经肽类和胺类等，其中对神经肽类如SP、ENK、CGRP、CCK等的研究已被许多学者所重视。SOC的基础研究可能会为临床神经耳科疾患特别是耳聋的诊治提供理论依据和重要线索。

参考文献：

［1］张培林主编．神经解剖学．北京：人民卫生出版社，1987, 230～240

［2］Helfert RH, Schwartz IR. Morphological features of five neuronal classes in the gertil lateral superior olive. Amer J anat, 1987, 179: 55

［3］Kiss A, Majorossy K. Neuron morphology and sunaptic architecture in the medial superior olivary nucleus. Exp Brain pes, 1983, 52: 315

［4］Guinan JJ JR, Warr WB, Norris BE, et al. Differential olivacochlear projections from lateral versus medial zones of the superior olivary complex. J Comp Neurol,1983, 221: 358

［5］Adams JC. Cytology of periolivary cells and the organization of their projections in the cat. J Comp Neurol,1983, 215: 275

［6］Susan MF, Wild JM. Reciprocal connections between primary and secondary auditory pathways in the telencephalon of the budgerirgar. Brain Res, 1997, 747: 18

［7］刘伟．听觉神经径路上的神经信息物质．国外医学耳鼻咽喉科学分册，1989, 13：321

［8］Altschaler RA, Parakkal MH, Fex J. Locolization of enkephlinlike immunoreactivity in acetylcholinesterase-positive cells in the guinea pig lateral superior olivary complex that project to the cochlea. Neurosciences, 1983, 9: 621

［9］Helfert RH, Bonneau JM, Wenthold RJ, et al. GABA and glycine immunoreactivity in the guinea pig superior olivary complex. Brain res, 1989, 501, 269

［10］邱建华，王锦玲，施际武，等．豚鼠脑干听觉中枢及内侧膝状体P物质受体阳性产物的分布．第四军医大学学报，1997, 18: 9

［11］Yoshifumi N, Takeshi K. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp neurol, 1994, 347: 249

［12］Lin HT, Brown JL, Jasmin L. Synaptic relationship between substance P and the substance P receptor: Light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc Natl Aead Sci USA Neurobiology, 1994, 91: 1009

［13］Caicedo A, Herbert H. Topography of descending projections from the inferior colliculus to auditory brainstem nuclei in the cat. J Comp neurol, 1993, 328: 377

［14］Kazuo K, Naoaki S, Chikako T. Immunohistochemical localization of γ-aminobutyric acid and asparate-containing neurons in the guinea pig superior olivary complex. Hearing res, 1993, 68: 173

［15］Steinbusch HWM. Distribution of serotonin-immunoreactyvity in the central nervous systems of the rat cell bodies and teriminals. Neuroscience, 1981, 6: 557

［16］Fallon JH, Seroogy KB. Visual and auditory pathwaya contain cholecystokinin: evidence from immunofluorescence and retrograde tracing. Neuroscience Letters, 1984, 45: 81

［17］Goldberg JM, Brown PB. Functional organization of the dog superior olivary complex:an anatomical and electrophysiological study. J neurophsiol, 1968, 31: 639

［18］Vetter D, Saldana E, Mugnaini E. Input from the inferior colliculus to medial olivocochlear neurons in the rat: a double label study with pHA-L and cholera toxin. Hearing Res, 1993, 70: 173

［19］Faingold CL, Anderson CAB, Caspary DM. Involvement of GABA in acoustically-evoked inhibition in inferior colliculus neurons. Hearing Res,1991, 52: 201

［20］Wang XY, Roberson D. Effects of bioamines and peptides on neurones in the ventral nucleus of trapezoid body and rostral periolivary regions of the rat superior olivary complex:an in vitro investigation. Hearing res, 1997, 106: 20

［21］武文明．耳蜗和中耳肽能神经元分布及其意义．国外医学耳鼻咽喉科学杂志，1991, 15: 321

［22］Schickinger B, Ehrenberger K, Felix D, et al. Substance P in the auditory hair cells in the guinea pig. ORL,1996, 58: 121

［23］Huffman RF, Henson OW. The descending auditory pathway and acousticomotor systems: connections with the inferior colliculus. Brain Res Review, 1990, 15: 195

［24］Kelly JB, Li L. Two sources of inhubition affecting binaural evoked responses in the rats inferior colliculus: the dosal nucleus of the lateral lemiscus and the superior olivary complex. Hearing res, 1997, 104: 112

［25］韩济生，关新民主编．医用神经生物学．武汉：武汉出版社，1996, 13～17

［26］Rouiller EM, Capt M, Dolivo M, et al. Neuronal organization of the stapedius reflex pathways in the rat: a retrograde HRP and viral transneuronal tracing study. Brain res, 1989, 476: 21

［27］Rouiller EM, Capt M, Dolivo M, et al. Tensor tympani reflex pathways studied with retrograde horseradish peroxidase and transneuronal viral tracing techniques. Neuroscience Letters, 1986, 72: 247

［28］Warr WB, White JS, Nyffeler MJ. Olivocochlear neurons: quantitative comparison of the lateral and medial efferent systems in adult and newborn cats. Soc Neurosci abstr, 1982, 8: 346