摘要：肿瘤的转移是其致死性的主要原因，其过程包括从肿瘤的原发部位脱离，进入周围的基质，进入循环或淋巴系统，粘附在内皮细胞壁并向血管外迁移及在远处侵润，血管增生，形成新的转移灶。这一过程包含复杂的分子机制，计多粘附分子、蛋白溶酶、细胞因子和生长因子参与了这一过程，本文将从粘附分子、蛋白溶酶和血管增生三方面将近年来的发展加以综述。参考文献：

［1］Sommers CL, Thompson EW, Torri JA, et al. Cell adhesion molecules uvomorulin expression in human breast cancer lines:relationship to morphology and invasive capacities. Cell growth and Differ,1991,3:365

［2］Mbalaviele G,Dunstan CR,Sasaki A,et al. E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res,1996,56:4064

［3］Bracke ME,Charlier C,Bruyneel EA,et al. Tamoxifen restores the E-cadherin function in human breast cancer mCFT/6 cells and suppresses their invasive phenotype. Cancer Res, 1994,54,4607

［4］Charlier C,Bruyneel E,Lechanteur C,et al. Enhancement of tamoxifen-induced e-cadherin function by Ca2+ channel antagonists in human breast cancer MCF7/6 cells. Eur J Pharmacol,1996,317:413

［5］Doki Y,Shiozaki H,Tahara H,et al. Correlation hetween E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer res, 1993,53: 3421

［6］Cheng L,Nagabhushan M,Pretlow TP,et al. Expression of Ecadherin in primary and metastastic prostate cancer. Am J Pathol,1996,148:1375

［7］Matsui S, Shiozaki H, Inoue M, et al. Immunochemical evaluation of alpha-catenin expression in human gastric cancer. Virchows Arch, 1994,424 :375

［8］Shimazui T,Schalken JA,Giroldi LA,et al. Prognostic valve of cadherin-associated molecules(alpha-catenin, beta, and gammacatenins and p 120cas)in bladder tumors. Cancer res, 1996,56;4154

［9］Dorudi S,Hanby AM,Poulsom R,et al. Level of expression of E-cadherin mRNA in colorectal cancer correlated with clinical outcome. Br J Cancer,1995,71:614

［10］Pignateli M,Ansari TW,Gunter P,et al. Loss of E-cadherin,alpha-catenin expression in panceratic cancer, correlation with lymph node metastasis, high grade and advanced stage. J pathol, 1994,174:243

［11］Nakanishi Y,Ochiai A,Akimoto S,et al. Expression of E-cadherin, alpha-catenin,beta-catenin and plakoglobin in esophageal carcinoma and its prognostic signifivance:immunohistochemical analysis of 96 lesions. Oncology, 1997,54:158

［12］Rimm DL,Sinard Jrt,Morrow JS. Reduced alpha-catenin and Ecadherin expression in breast cancer. Lab Invest, 1995,72 :506

［13］Su LK,Vogelstein B,Kinzler KW,et al. Association of the APC tumor suppressor protein with catenin. Science, 1993,262:1734

［14］Rubinfeld R, Robbins P, El-gamil M, et al. Stabilization of β-catenin by genetic defects in melanoma cell lines. Science, 1997,275:1790

［15］Morin PJ,Sparks AB,Korinek V,et al. Activation of β-catenin or Tcf signalin in colon cancer by mutations in β-catenin or aPC. Science, 1997,275:1787

［16］Chen H,Paradies NE,Fedor-Chaiken M,et al. E-cadherin mediates adhesion and suppressed cell motility via distinct mechanism. J Cell Sic,1997,110:345

［17］Shoukat Dedhar. Integrins and signal transduction. Current Opinion in Hematology, 1999,6:36

［18］Gui GPH,WelIs CA,Yeoman P,et al. Integrin expression in breast cancer cytology-a novel predictor of axillary metastasis.Eur J Surg Onco1,1999,22:254

［19］Weinel RJ,Rosendahl A,Pinschimidt E,et al. The alpha 6-integrin receptor in pancreatic carcinoma. gastroenterology, 1995,108:523

［20］Lindmark G,Gerdin B,Pahlman L,et al. Intercohnection of integrins alpha 2 and apha 3 and structure of the basal membrane in colorectal cancer, relation to survival. Eur J Surg Oncol,1993,19:50

［21］Suzuki S,takahashi T,Makamura S,et al. Alteration of integrin expression in human lung cancer. Japanese J Cancer res, 1993,84:16

［22］Zutter M,Mazoujian G,Santoro SA. Decreased expression of integrin adhesive protein receptors in adenoearcinoma of the breast. Am J Pathol,1990,137:863

［23］Giancotti FG,Ruoslahti E. Elavated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Ce11,1990,60:849

［24］Friedrichs K,Ruiz P,Franke F,et al. High expression level of α6 integrins in human breast carcinoma correlated with reduced survival. Cancer res, 1995,55: 901

［25］Van Waes C,Kozarsky KF,Warren AB,et al. The A9 antigen associated with aggressive human squamous carcinoma in structurally and functionally similar to the newly defined integrin α6β4. Cancer res, 1991,51,2395

［26］Albelda SM,Mette SA,Elder DE,et al. Integrin distribution in malignant melanoma,association of the β3 subunit with tumor progression. Cancer res, 1990,50: 6757

［27］Tomita Y,Saito T,Saito K,et al. Possible significance of BLA-4(α4β1) for hematogenous metastasis of renal-cell cancer. Int J Cancer, 1995,60: 753

［28］冷启新，刘执玉，李瑞祥．粘附分子在淋巴细胞穿越血管内皮过程中的作用的研究进展．微循环学杂志，1999，9(2)：37

［29］Dejana E,Martin PI,Lauri D,et al. Endothelial leukocyte adhesion molecular-1 dependent adhesion by an antibody to lewis fucosylated type I carbohydrate chain. Lab Invest, 1992,109,437

［30］Sakamoto S, Watambe T, Tokumaru T, et al. Expression of Lewisa Lewisb, lewisx, Lewisy, siayl-Lewisx blood group antigen in human gastric carcinoma and in normal gastric tissue.Cancer res, 1989,49: 745