摘要：目的 探讨乳头状肾细胞癌的临床病理特征及诊断标准。方法 收集5例该肿瘤，作常规HE及免疫组织化学染色并与70例非乳头状肾细胞癌比较。结果 乳头状肾细胞癌是一种特殊类型的肾细胞癌，临床经过长，生长缓慢，肾动脉造影表现为少血管或无血管性，预后较好。巨检肿瘤边界清楚，有出血囊性变。镜检肿瘤组织呈乳头状或管状乳头状排列，乳头轴心及间质内有泡沫状巨噬细胞浸润，有明显出血坏死。结论 乳头状肾细胞癌在临床，血管造影，病理形态，生物学行为上均与其他类型的肾细胞癌不同，应将其作为一种独立的组织学类型诊断。

分类号：R730．261文献标识码：A

文章编号：1007-8096(2000)01-0027-03

Clinical and histopathological studies of papillary renal cell carcinoma—A report of 5 cases

zhang Huizhen,Jiang Zhimin,Zhang Liping(Departnent of Pathology, Shanghai Sixth People' s Hospital, Shanghai 200233)

Abstract：Objective To study the clinical pathological characteristics and the diagnostic standards of papillary renal cell car-cinoma(RCC). Method Histopathologic and immunohistochemical changes of 5 cases of papillary RCC were compared with those of 70 cases of non-papillary rCC. Results Papillary RCC is a special renal cell carcinoma. The course of the disease is longer and slow. The fact that Papillary RCC has a better prognosis than conventional RCC suggests that it is a tumor with lower malignant potential. It is radiographic hypovascular. On gross appearance, the tumor is completely or predominantly well circum-scribed, often with a thick fibrous capsule, hemorrhage and variable cystic degeneration. The histologic architecture is papillary or tubupapilary. In the papillary core or space between papillae there is infiltration of foam cells. Other constant features of papillary RCC is hemorrhage and necrosis. Conclusions Papillary RCC differs from non-papillary RCC in clinical course, radiographic and pathologic morphology and biologic behavior.Therefore, it should be classified as an independent histological type of rCC.

Keywords：Papillary renal cell carcinoma Pathologic diagnosis Immunohistocbemistry参考文献：

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收稿日期：1999-07-26

修稿日期：1999-09-27