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不同浓度氯化钙溶液对羊血浆法测定肝素钠效价的影响

2022-07-29
来源:求医网
摘要:目的:探讨不同浓度的氯化钙溶液对羊血浆法测定肝素钠效价的影响。方法:参照美国药典方法,将其中的0.25%氯化钙溶液用0.50%氯化钙溶液替代。结果:用两种浓度的氯化钙溶液所得结果一致。结论:采用0.50%氯化钙溶液可替代0.25%氯化钙溶液,且比现行方法具有降低羊血浆半凝固度剂量的优点。

分类号:R927.1

Studies on the Influence of the Concentration of CaCl2 Solution on the Determination of Heparin Sodium Potency with Sheep Blood Plasma

guo Fengxian,Cui Xiangzhen,Liu Li(Shandong Freda Fine Chemicals Co. ,Ltd. Jinan 250014)

Abstract:Purpose: To study the influence of the concentration of CaCl2 solution on the determination of heparin sodium potency with sheep blood plasma. Methods: To refer to the method stipulated by USP with 0.50% CaCl2 solution instead of 0.25% CaCl2 solution. Results: The result was consistent with 0.50% CaCl2 solution as well as 0.25% CaCl2 solution. Conclusion: 0.50% CaCl2 solution can substitute for 0.25% CaCl2 solution and has the superiority of reducing the volume of 0.50 clotting.

Keywords:Heparin sodium, Potency, Determination, Concentration参考文献:

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收稿日期:1999-09-20