关键词: 胸腺肽微球，药代动力学，生物利用度，大鼠

摘要：目的：研究胸腺肽微球在大鼠体内的药动学和生物利用度。方法：用高效液相色谱测定大鼠血中胸腺肽浓度，3P87程序计算参数。结果：胸腺肽微球的药动学参数分别为：Cmax＝28.60±9.43ug／ml，tmax＝210min，tl/2(β)＝144.40±19.78min，AUC0～∞＝7662.03±704.36ug·min／ml，相对于胶囊剂内容物的生物利用度是238.8％。结论：大鼠对胸腺肽微球的吸收明显优于胶囊剂内容物。

Pharmacokinetics and Bioavailability of Oral Microspheres of Thymopeptide in Rat

zhang Haisong,Liu Weihong,Zhang Jizhan,Liu Huiping,Zhang Yijun(Institute of Hepatic Diseaes,Guangzhou Hospital of Air Force(Guangzhou 510602))

Abstract：To study on the pharmacokinetics and bioavailability of oral microspheres of thymopeptide in rat.Methods:Thymopeptide concentration of rat plasma was determined by HPLC and computerized pharmacokinetics parameters with 3P87 program. Results: The pharmacokinetics parameters of oral microspheres of thymopeptide were:Cmax＝28.6±9.43ug／ml,tmax＝210min,t1/2(β)＝144.40±19.78min,AUC0～∞＝7 662.03±704.36ug·min／ml,and bioavailability compared with capsule was 238.8％.Conclusion:Absorption of thymopeptide in microspheres has an advantage over that of thymopeptide in capsule in rat.

Keywords：Thymopeptide microspheres,Pharmacokinetics,Bioavailability,Rat

参考文献：

［1］李惠雄．胸腺肽口服剂型和临床实验．中国药学杂志,1991,26(4):199～201

［2］于华生，陈紫榕．胸腺多肽肠吸收的初步研究．中国生化药物杂志,1994,15(1):32～33

［3］倪宏，孟祥顺，赵芳．胸腺素口服对小鼠免疫功能的影响．中国生化药物杂志,1996,17(2):59～62

［4］张海松，陈阳述，胡军高，等．口服胸腺肽微球的研究．中国药房,1999,10(2):58～59

收稿日期：1999-07-13

修稿日期：1999-09-20