关键词: 低分子肝素，临床应用

摘要：结合文献与作者实践，综述了低分子肝素的临床应用。低分子肝素在防治血栓栓塞性疾病中效果良好，与肝素相比，在临床应用上有一定的优势。

Clinical Application of Low Molecular Weight Heparin

liang Jiangjiu,Zhang Lei,Zhang Meihong(Shandong Provincid Qianfoshan Hospital(Jinan 250014)

参考文献：

［1］Cosmi B,Hirsh J.Low molecular weight heparins.Current Opinion in Cardiology,1994,9:612～618

［2］张天民，王凤山，凌沛学．低分子肝素研究进展．中国生化药物杂志,1998,19(4):194～196

［3］王鸿利．低分子量肝素的临床应用．临床血液学杂志,1997,10(4):146～151

［4］冯仁田，王福清．低分子量肝素的作用机制及其临床研究进展．中国生化药物杂志,1998,19(5):217～219

［5］尤蓓，于金德．低分子量肝素与心血管病．国外医学——心血管疾病分册,1997,24(5):19～22

［6］Anthonic WA,Lensing MD,Martin H,et al.Treatment of deep venous thrombosis with low molecular weihgt heparins.Arch Intern Med,1995,155:601～607

［7］The European Fraxiparin study Group.Comparison of a low molecular weight heparin and unfractionated heparin for the prevention of deep vein thrombosis in patients undergoing abdominal surgery.BrJ Surg,1988,75(11):1058～1063

［8］朱兰英，吴永贵，毛海萍，等．单剂量低分子量肝素在血液透析抗凝中的作用．中华肾脏病杂志,1996,12(1):32～35

［9］万建新，高丽真，郭淑霞，等．低分子量肝素在高危出血患者血液透析中的应用．血栓与止血学杂志,1997,3(3):15～17

［10］杨筱伟，陈香美，徐启河，等．低分子量肝素对增殖性肾炎的疗效观察．中华内科杂志,1997,36(11):731～734

［11］曾群英，麦炜颐，李玉杰，等．速避凝治疗不稳定型心绞痛的临床研究．血栓与止血学杂志,1997,34(3):7～11

［12］董呼钢，马虹，叶慧膺，等．低分子肝素治疗急性心肌梗塞后无 症状性心肌缺血的初步观察．岭南心血管病杂志,1997,3(3):4～5

［13］Nesvold A,Kontny F,Abildgaard U,et al.Safety of high doses of low molecular weight heparin (Fragmin) in acute myocardial infarction.Thromb Res,1991,64(5):579～587

［14］Ferguson JJ.The 1995 European society of cardiology.Circulation,1995,92(9):2359～2363

［15］Morice MC,Zemour G,Benveniste E,et al.Intracoronary stenting without coumadin.Cathet Cardiovasc Diagn,1995,35(1):1～7

［16］Sakuragawa N,Hasegawa H,Maki M,et al.Clinical evaluation of low-molecular-weight heparin(FR-860) on disseminated intravascular coagulation(DIC).Thromb Res,1993,72(6):475～500

［17］Oguma Y,Sakuragawa N,Maki M,et al.Clinical effect of low molecular weight heparin(Fragmin)on DIC.Thromb Res,1990,59(1):37～49

［18］赵斌，邢永前，陈富嫦，等．速避凝治疗急性脑梗塞的临床观察．血栓与止血学杂志,1997,3(3):12～14

［19］Kay R,Wong ks,Woo J.Pilot study of low-molecular-weight heparin in the treatment of acute ischemic stroke.Stroke,1994,25(3):684～685

［20］Pezzuoli G,Neri Serneri GG,Settembrini P,et al.prophylaxis of fatal pulmonary embolism in general surgery using low-molecalar weight heparin CY216.Int Surg,1989,74(4):205～210

收稿日期：1999-01-20

修稿日期：1999-06-20 1999-07-15